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What causes PBC liver disease? Primary biliary cholangitis (PBC) is inflammation with progressive scarring of the bile ducts in the liver. Primary biliary cholangitis (PBC) probably results from an autoimmune reaction. This disorder commonly causes itchiness, fatigue, dry mouth and eyes, and jaundice, but some people have no symptoms. Can naproxen cause elevated liver enzymes? Naproxen -induced liver injury. BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) have been reported to induce liver injury. Patterns of the injury usually range from mild elevations of liver enzymes to sometimes severe fulminant hepatic failure.
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