Does diltiazem cause weight gain? Yes. Weight gain can occur as a side effect of some beta blockers, especially the older ones, such as atenolol (Tenormin) and metoprolol (Lopressor, Toprol-XL). The average weight gain is about 2.6 pounds (about 1.2 kilograms). Is diltiazem addictive? Diltiazem is a benzothiazepine derivative with antihypertensive and vasodilating properties. Approved in 1982 by the FDA, it is a member of the non-dihydropyridine calcium channel blockers drug class.
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