Can I get penicillin over the counter? Penicillin is a prescription antibiotic and should not be used casually. Because of this, penicillin V is not an over-the-counter (OTC) medication and one cannot legally buy penicillin online in the United States. Does trimethoprim affect the pill? Trimethoprim doesn't affect hormonal contraceptives such as the pill. However, if you experience vomiting or diarrhoea while taking this antibiotic, this can potentially make your pill less effective at preventing pregnancy.
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