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What happens if you take methotrexate and folic acid on the same day? It is considered that the folic acid dose should be high enough to prevent folate deficiency. They state that folic acid can be given any day as long as it is not on the same day as methotrexate. Folic acid reduces toxic effects and improves continuation of therapy and compliance.
Does methotrexate affect the immune system? Methotrexate does suppress the immune system, but serious infections with methotrexate are not common. Almost all autoimmune diseases require the immune system be suppressed to some degree, because 'overactivity' of the immune system is what drives the illness.
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