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How does Parkinson's disease affect the autonomic nervous system? Autonomic Nervous System Dysfunction in Parkinson's Disease. Autonomic nervous system dysfunction in PD may be caused by an underlying degenerative process that affects the autonomic ganglia, brainstem nuclei, and hypothalamic nuclei. Anti- parkinsonian medications can cause or worsen symptoms of ANS dysfunction. Can a 30 year old have Parkinson disease? Scientists have discovered genes that can cause or increase the risk of developing Parkinson's at a younger age. In fact, a recent study found that 65 percent of people with PD onset under 20 years old and 32 percent of people with onset between 20 and 30 had a genetic mutation believed to increase PD risk. However.
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