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What is acute allograft rejection? Transplant rejection. Transplant rejection occurs when transplanted tissue is rejected by the recipient's immune system, which destroys the transplanted tissue. Transplant rejection can be lessened by determining the molecular similitude between donor and recipient and by use of immunosuppressant drugs after transplant
What are immune suppressing drugs? Introduction. Immunosuppressant drugs are a class of drugs that suppress, or reduce, the strength of the body's immune system. Some of these drugs are used to make the body less likely to reject a transplanted organ, such as a liver, heart, or kidney. These drugs are called antirejection drugs.
How does the immune system respond to a kidney transplant? The immune response to transplanted organs is mediated by antibodies, T cells, and innate immune cells. Specifically, a disturbed T cell homeostasis plays a role in the acute rejection of transplanted organs. T-helper cells and regulatory T cells are the primary components of the T cell balance in the body.
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