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How long does lidocaine take to wear off? approximately 1 to 3 hours Are bupivacaine and lidocaine the same? The most commonly used local anesthetic agents are Lidocaine and Bupivacaine. On the other hand, Bupivacaine, has a slower onset of action (about 5-10 minutes after injection) but its effects last much longer, for about 4-8 hours.
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